Cartilage loss and bone fractures regenerate as long as genetic integrity is maintained, that’s why it’s widely considered an age related disease. Self repairing telomeres would keep you from having most later in life joint failures.

As for arthritis and general aches and pains, those are more common after the human body stops developing, usually in the late twenties and early thirties and progressing onwards. You can also contribute to these pains by misusing or overusing joints, such as tennis elbow.